Research Progress in the Treatment of BPH with Xialiqi
Original Science and Technology Traditional Chinese Medicine for the Prevention and Treatment of Prostate Diseases-Xialiqi Capsules.
lInnovative drugs with independent intellectual property rights developed under the guidance of the theory of collateral diseases-Qi collateral theory;
lThe formula combines “treating, tonifying, and removing”, and treats both symptoms and the root cause, reflects the advantages of treatment over traditional methods of clearing heat and promoting diuresis;
lResearch shows that Xialiqi can not only rapidly relieve symptoms such as urinary frequency, urgency urination and acraturesis, but also shrink glands and delay the progress of hyperplasia. It has the therapeutic advantage of quick fix and long-term nourishment, and is the best choice for clinical treatment of BPH.
Theoretical Innovation There Is a New Article in July
“Research on the mechanism and innovative diagnosis and treatment strategies of integrated traditional Chinese and western medicine for prostate diseases”
First Prize of the Science and Technology Award of the Chinese Association of the Integration of Traditional and Western Medicine in 2020.
Key Technologies and Innovation Points
A new theory of “deficiency-diuresis-stasis” is proposed on prostate disease from the perspective of integrated traditional Chinese and Western medicine。
A traditional Chinese and western medicine syndrome differentiation system is established for prostate disease and the mechanism of disease progression is explained。
A new system of integrated diagnosis and treatment of prostate diseases with traditional Chinese and western medicine is established。
A new drug for prostate disease, Xialiqi, is developed and industrialization is realized。
The Characteristics of Treatment with Xialiqi Formula from the Perspective of Qi Collateral Theory
The Characteristics of Treatment with Xialiqi Formula from the Perspective of Qi Collateral Theory
Characteristics of pathogenesis: Qi deficiency in the spleen and kidney, phlegm and blood stasis blocking collaterals;
Characteristics of the formula: Focus on regulation and nutrition and supplemented with removing stasis;
Principle of treatment: Invigorate spleen and benefit kidney, promote urination and remove stasis.
Treatment philosophy: Quick fix and long-term nourishment。
Significant Diuretic Effects, Increasing Urinary Na, K, C1 Ion Excretion of Xialiqi
ØEffect on Urinary Output in Water-loaded Rats
Result analysis: Xialiqi Capsules had diuretic effect among low, medium and high dose groups.
The diuretic effect was stronger at 2 h, indicating that Xialiqi can realize rapid urination (P <0.05)
Xialiqi is Anti-proliferative and Pro-apoptotic to Stop the Development of Prostatic Hyperplasia
ØXialiqi Regulates the Level of Proliferation/ Apoptosis Protein in Prostate Tissue
A: Blank Control Group; B: Model Control Group; C: Xialiqi High Dose Group; D: Xialiqi Low Dose Group; E: Finasteride Group
Serum DHT levels were significantly lower in the Finasteride and Xialiqi groups than that in the model group (P <0.01), but there was no significant difference between the high dose Xialiqi and Finasteride groups (P >0.05).
Prostate DHT levels were significantly lower in the Finasteride and Xialiqi groups (P <0.01)
Xialiqi can Reduce Prostate Weight/Index and Significantly Inhibit Prostate Cell Hyperplasia
Evidence-based Study Confirmed: Xialiqi can Effectively Reduce IPSS Score and Improve Treatment Response Rate.
Trial Facility: 5 Grade III Class A hospitals including Guang’anmen Hospital, China Academy of Chinese Medical Science
Drug Administration in Groups: Treatment Group (330 cases): Xialiqi Capsules (3 capsules/time, 3 times/day)
Control Group (110 cases): Control drug (3 capsules/time, 3 times/day) Course of treatment: 4 weeks
Significant Reduction of IPSS Score and Significant Improvement of Clinical Symptoms
Increase of Maximum Urinary Flow Rate, Decrease of Residual Urine Volume, and Reduction of Prostate Size
Xialiqi Capsules Combined with Tamsulosin for the Treatment of BPH.
Significant Improvement of Clinical Symptoms with Less Adverse Effects
Sharing of Typical Cases of Xialiqi Capsules
ØOn November 8, 2018, the patient, male, 65 years old, reported more than 40 nocturnal urinations, acraturesis, few bladder fillings, and that he could not tolerate continuing to hold urine
pStudies have shown that administration at full dose and complete course of treatment can improve the efficacy
Administration of Xialiqi Capsules with 9 capsules/day for 4 weeks can reduce the IPSS score and Chinese medicine symptom complex score of BPH patients, increase the urinary flow rate, improve the quality of life of patients, and alleviate LUTS, with an overall response rate of 92.9%, which outperforms the Chinese medicine pr Qianlie Shule Granules (81.2%, 4 g, tid), with no significant adverse reactions and good safety
Prescription recommendation: Xialiqi Capsules, oral administration, 3 capsules/time, 3 times a day for 4 weeks as a course of treatment;
BPH patients who need long-term treatment can follow long-term administration.
Quick Fix and Long-term Nourishment Make Urination More Comfortable and Smooth.
Xialiqi Capsules for Urinary Frequency, Urinary Urgency and Poor Urination
Preferred Medication for Treatment of Prostate Disease
|
Drug Category |
Representative Drug |
Mechanism of Action |
Drug Characteristics |
Adverse Reactions |
|
5-α Reductase inhibitors |
Finasteride |
Reduce prostate size by lowering prostate and androgen levels in the body |
6-months continuous application is required to take effect, and symptoms recur after discontinuation of medication; Prostate volume less than 30 mL cannot be prevented and the effect on improving symptoms is poor. |
① It takes effect slowly, and it is required to take medicine for a long time, which may cause hormonal side effects such as sexual dysfunction and impotence. ② The FDA has announced on its official website that long-term use of 5-α Reductase inhibitors may increase the risk of developing high-grade prostate cancer. |
|
α1-Adrenal receptor antagonist |
Tamsulosin (Harnal) |
Relieve the dynamic factors of bladder outlet obstruction caused by BPH by relaxing the smooth muscles of the prostate and urethra, to improve the symptoms of obstruction |
Symptoms can be improved in a few days, but urodynamic indicators (prostate size, serum PSA level) cannot be changed, and the natural course of the disease cannot be altered. |
① The symptoms are improved without shrinking the enlarged prostate gland, that is to say, it can only treat symptoms but not the root cause. ② It may lead to cardiovascular side effects, such as postural Hypotension, dizziness and headache. |
|
Phosphodiesteras
|
Sildenafil |
The exact mechanism is not yet well understood |
It can significantly improve LUTS, but has no significant effect on urodynamic changes |
Facial flushing, gastroesophageal reflux, headache, and indigestion are typically common. |
|
Plant medicine and traditional Chinese patent medicines |
Xialiqi Capsules |
Clear heat and treat stranguria, promote blood circulation and resolve blood stasis Invigorate spleen and benefit kidney, remove stasis, and relieve pain |
Traditional Chinese medicine has multiple components, multiple targets, and takes effect through overall regulation. They have small side effects, no sexual dysfunction and feminization, especially for the treatment of primary and secondary prostatic hyperplasia. |
High safety and minimal adverse reactions |
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